IMPAIRED SKELETAL MUSCLE MITOCHONDRIAL PYRUVATE UPTAKE REWIRES GLUCOSE METABOLISM TO DRIVE WHOLE-BODY LEANNESS

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

Metabolic cycles are a fundamental element of cellular and organismal function.Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose.Here, skeletal muscle-specific Mitochondrial Pyruvate copyright (MPC) deletion in mice diverted pyruvate Mugs into circulating lactate.This switch disinhibited

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DNA Polymerases as Engines for Biotechnology

MISC This review examines the DNA polymerases, a class of enzymes that has been an essential tool for molecular biology research.Several families of DNA polymerases have been defined based on amino acid sequence comparisons, and new enzymes are continually being discovered, driving the expansion of the current classifications.Structural similaritie

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Fuzzy and Sample Entropies as Predictors of Patient Survival Using Short Ventricular Fibrillation Recordings during out of Hospital Cardiac Arrest

Optimal defibrillation timing guided by ventricular Mugs fibrillation (VF) waveform analysis would contribute to improved survival of out-of-hospital cardiac arrest (OHCA) patients by minimizing myocardial damage caused by futile defibrillation shocks and minimizing interruptions to cardiopulmonary resuscitation.Recently, fuzzy entropy (FuzzyEn) ta

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